与免疫相关的严重不良事件相关的因素 (综述)
Zhenzhen Su1, Miaomiao Guan1, Liyan Zhang2
1School of Nursing, Peking University, Beijing 100191, P.R. China.
Molecular and clinical oncology
|November 20, 2024
概括
免疫检查点抑制剂 (ICI) 可以在10-43%的癌症患者中引起严重不良事件 (ir-SAE). 确定患者特异性风险因素对于早期干预和改善免疫治疗安全至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症疗法,但经常导致与免疫相关的不良事件 (irAEs),严重的irAEs (ir-SAEs) 发生在10-43%的患者中.
- 由于它们的频率,潜在致命性和非特异性,快速进展的性质,ir-SAE带来了重大风险,需要及早识别高风险个体.
研究的目的:
- 通过ICI治疗的癌症患者中,审查和综合与ir-SAE相关的已知因素.
- 提供临床参考,用于识别患有发展ir-SAEs风险较高的患者.
主要方法:
- 进行了一项文献审查,以确定ir-SAEs的风险因素.
- 这些因素被分类为人口特征,疾病相关信息和实验室检查.
主要成果:
- 人口因素包括年龄,BMI,吸烟,种族和家族史.
- 与疾病相关的因素包括病史,治疗方案和癌症类型.
- 实验室发现包括周围血液细胞,免疫细胞,细胞因子,遗传学,肠道微生物群,蛋白质和脑损伤标志物,所有这些都可能影响炎症反应和免疫平衡.
结论:
- 对人口,疾病相关和实验室因素的分析可以帮助预测ir-SAEs.
- 由ICI破坏肠道微生物群的破坏可能会导致ir-SAE.
- 建议对这些风险因素进行常规分析,以便早期识别和个性化干预,以提高免疫治疗患者的安全性.
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