阻塞性睡眠呼吸暂停对心血管健康的影响:系统性审查
Swati Thareja1, Ramya Mandapalli2, Fahmida Shaik3
1Internal Medicine, The Hans Foundation, Delhi, IND.
Cureus
|November 20, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 通过炎症和氧化应激等机制显著增加心血管疾病的风险. 早期诊断和治疗OSA对于管理高血压和其他心脏疾病至关重要.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 涉及睡眠期间重复停止呼吸,与心血管并发症密切相关.
- 睡眠呼吸暂停是最常见的睡眠呼吸暂停形式,与高血压,心律失常和心力衰竭有关.
- 病理生理联系包括间歇性低氧化,交感神经系统激活,炎症和心室重塑,导致氧化应激和内皮功能障碍.
研究的目的:
- 系统地审查阻塞性睡眠呼吸暂停和心血管疾病 (CVD) 之间的联系.
- 确定将OSA与心血管疾病连接起来的病理生理机制.
- 评估OSA对心血管风险因素和结果的影响.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在PubMed,Scopus,Embase和Cochrane图书馆搜索了过去15年发表的研究.
- 包括使用关键词的研究:"睡眠障碍"",呼吸暂停"",高血压"",心血管疾病 (CVD) "和"治疗结果".
主要成果:
- 10项研究满足了128项确定的纳入标准.
- 一致的证据强调了OSA在加剧心血管风险方面的重要作用.
- 在患有并发性肥胖,高血压和糖尿病的患者中,增加的风险尤其显著.
结论:
- OSA是导致心血管疾病发展和进展的主要因素.
- 了解OSA的病理生理机制是减轻心血管风险的关键.
- 有效管理OSA可能会改善心血管结果,特别是在高风险人群中.
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