与代谢功能障碍相关的脂肪性肝病患者的身体组成差异
Karen D Bernal-Contreras1, Montserrat Berrospe-Alfaro2, Regina López de Cárdenas-Rojo2
1Facultad de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan, Mexico.
Frontiers in nutrition
|November 20, 2024
概括
代谢功能障碍相关的性肝病 (MASLD) 患者的身体组成因BMI而异,可能是由于骨肌肉质量损失. 高腰围和肝硬化与改变的身体组成有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 与人体成分 (BC) 有关.
- 关于MASLD患者在不同身体质量指数 (BMI) 水平的BC差异的证据有限.
- 了解这些变异对于管理MASLD及其并发症至关重要.
研究的目的:
- 为了研究MASLD患者身体组成 (BC) 的差异.
- 分析与身体质量指数 (BMI) 和代谢状态相关的BC变化.
- 为了确定与MASLD中异常BC相关的因素.
主要方法:
- 对参加检查单位的316名患者进行横截面研究.
- 通过受控衰减参数评估的肝脏肥胖症.
- 根据BMI,MASLD存在和代谢健康 (非MASLD,MASLD<25 kg/m2,超重-MASLD,代谢健康的肥胖者-MASLD,代谢不健康的肥胖者-MASLD) 患者被分为五组.
- 使用生物电阻和生物阻抗矢量分析 (BIVA) 分析的身体组成.
- 统计分析包括单向ANOVA和单变量/多变量分析.
主要成果:
- 在BMI<25 kg/m2-MASLD和超重-MASLD两组之间,脂肪百分比没有显著差异.
- 与正常体重和超重体重相比,肥胖的MASLD组的骨肌肉质量 (SMM) 较低.
- 与非MASLD和正常体重MASLD组相比,在代谢上健康的肥胖者-MASLD和代谢上不健康的肥胖者-MASLD组中,细胞外水/细胞内水的比率更高.
- 腰围异常 (WC) 和肝肥胖症是与BC异常相关的独立因素.
结论:
- 随着BMI的增加,MASLD患者的身体组成会发生变化,这主要是由于潜在的骨肌肉质量损失,而不是仅仅是代谢异常.
- 高腰围和肝脏肥胖症的存在是MASLD中改变身体组成的关键独立预测因素.
- 这些发现强调了监测MASLD管理中的身体成分的重要性,考虑到BMI,WC和肝脏健康.
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