随机对照试验双额头跨直接电流刺激对渴望酒精使用障碍的渴望
Arundhati Gairola1, Anil Nischal1, Sujita Kumar Kar1
1Dept. of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.
Indian journal of psychological medicine
|November 20, 2024
概括
超直流刺激 (tDCS) 在急性酒精使用障碍 (AUD) 患者中减轻酒精渴望方面显示出希望. 这种神经调节技术是安全的,耐受性很好,提供了潜在的新管理选择.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 成 药物 药物 药物 药物
背景情况:
- 酒精使用障碍 (AUD) 在渴望管理方面提出了重大挑战.
- 像跨直流刺激 (tDCS) 这样的神经调节技术正在探索AUD治疗.
- 评估tDCS的疗效和对幸福感的影响对于AUD患者护理至关重要.
研究的目的:
- 评估tDCS在减少AUD患者饮酒渴望方面的有效性.
- 为了确定tDCS干预对AUD的安全性和耐受性.
- 在AUD中测量tDCS治疗后主观幸福感的变化.
主要方法:
- 随机对照试验比较活跃的tDCS与假装的tDCS,每组17名AUD患者.
- 在一周的时间内进行了五次tDCS疗程,针对2mA电流的背侧前额皮层 (DLPFC).
- 在第1,4和第8周评估酒精冲动 (AUQ) 和幸福感 (WHO-5) 以及副作用检查表.
主要成果:
- 与假药相比,活性tDCS在第1周和第4周显著减少了酒精的冲动,但在第8周却没有.
- 两组人都表现出改善的幸福度,活跃和假的tDCS之间没有显著差异.
- 观察到的副作用是轻微的,短暂的,不需要特殊的管理.
结论:
- tDCS可能是有效的急性管理的酒精渴望在AUD.
- 这种干预措施是安全的,并且被AUD患者容忍得很好.
- 需要进一步的研究,以了解AUD治疗中tDCS的长期疗效和最佳方案.
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