骨髓干细胞治疗关节骨关节炎的有效性:一个范围广泛的评论
Olivia F Perez1, Christopher Warburton1, Marc C Philippon1
1Miller School of Medicine, University of Miami, Miami, FL, USA.
概括
骨髓衍生干细胞 (BM-MSC) 疗法对关节骨关节炎 (HOA) 有望,改善疼痛和功能. 然而,使用了低剂量,需要对最佳剂量和长期影响进行更多研究.
科学领域:
- 整形外科 整形外科 整形外科
- 再生医学是一种再生医学.
- 生物技术是生物技术.
背景情况:
- 关节炎 (HOA) 是一种常见的退行性关节疾病.
- 骨髓衍生干细胞 (BM-MSC) 治疗是一种新的HOA生物治疗方法.
研究的目的:
- 分析对HOA的BM-MSC治疗的标准准备和实践.
- 为了确定BM-MSC治疗和临床结果之间是否存在剂量反应关系.
- 评估单独使用BM-MSC疗法治疗HOA的有效性.
主要方法:
- 根据PRISMA和Cochrane指南进行了范围审查.
- 在多个数据库 (PubMed,Embase,Scopus等) 进行了搜索. 对于HOA的BM-MSC注射的研究.
- 从涉及72名患者的7项研究中提取了研究特征,准备,剂量,结果和不良影响的数据.
主要成果:
- 所有包括的7项研究都报告了积极的临床结果.
- 患者在内关节BM-MSC注射后经历了疼痛减轻和功能能力改善.
- 结果措施包括数值疼痛尺度,WOMAC和VAS分数.
结论:
- 单独的BM-MSC治疗似乎对治疗关节骨关节炎有益.
- 所有研究都使用低剂量注射,防止对剂量-反应关系的分析.
- 需要进一步研究高剂量和长期随访,以建立最佳的治疗方案.
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