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用干细胞注射治疗膝关节骨关节炎的并发症:系统性审查

Clara Riggle¹, Maddison McLellan¹, Hunter Bohlen¹

¹Department of Orthopaedic Surgery, University of California, Irvine, Orange, CA, USA.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

|November 20, 2024

概括

膝关节骨关节炎 (OA) 的干细胞注射显示12.3%的临时副作用比如胀和疼痛. 没有报告重大并发症,但特定的干细胞类型具有更高的不良事件率.

科学领域:

整形外科整形外科整形外科
再生医学是一种再生医学.
临床研究临床研究

背景情况:

膝关节关节炎 (OA) 是导致疼痛和功能障碍的主要原因.
干细胞注射越来越多地用于膝关节OA,但并发症数据有限.

研究的目的:

系统地审查和描述膝关节OA干细胞注射的不良事件.
量化与这些治疗相关的并发症的频率和类型.

主要方法:

按照PRISMA指南进行系统审查.
搜索了PubMed和Cochrane图书馆的研究 (从2000年1月至2021年6月).
包括对膝关节OA的各种自身和异性干细胞类型的研究.

主要成果:

在1924名患者中,暂时不良事件 (胀,疼痛) 的总比率为12.3%.
带衍生和培养ADMSC注射显示出更高的不良事件率.
没有报告任何重大并发症,如感染,栓塞或死亡.

结论:

短时间的膝关节骨质炎治疗中介质干细胞注射没有重大风险.
存在过渡性注射部位胀和疼痛的中等风险.
长期安全性需要进一步调查.

关键词:

膝盖骨关节炎膝盖骨关节炎在安全方面,安全是安全的.干细胞注射是干细胞的注射.

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