轴性脊柱关节炎患者的疾病活动和骨微型结构现象
Linda Russell1, Insa Mannstadt1, Dalit Ashany1
1Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York City, NY, USA.
概括
轴性脊柱关节炎 (AxSpA) 患者的疾病持续时间较长,骨密度和微型架构较差. 这表明疾病进展会影响骨健康,需要对潜在机制进行进一步研究.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 轴性脊柱关节炎 (AxSpA) 是一种影响脊柱的慢性炎症性疾病.
- 矛盾的是,AxSpA与骨质疏松症和脊椎骨折有关.
- 在AxSpA中造成骨缺陷的原因尚不清楚.
研究的目的:
- 为了评估骨矿物质密度 (BMD) 和AxSpA患者的微架构.
- 确定与疾病活动和骨异常相关的因素.
- 研究IL-17治疗对骨健康的影响.
主要方法:
- 30名AxSpA患者接受了双能量X射线吸收计 (DXA) 和高分辨率外围定量计算断层扫描 (HR-pQCT).
- 测量了体积 BMD (vBMD),微架构和故障负载.
- 使用BASDAI,BASMI和BASFI分数来评估疾病活动.
主要成果:
- 大多数患者的BMD和微架构都在正常范围内.
- 患有AxSpA的男性显示出较低的总vBMD (-1.2 SD).
- 较长的疾病持续时间与部下部aBMD,缩小的椎vBMD和改变的微观架构相关.
结论:
- 在AxSpA的骨异常与疾病持续时间有关.
- 需要对更大的队列进行进一步的研究,以了解AxSpA.骨损伤的发病原因.
更多相关视频
08:52Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
2.9K
12:23Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
19.5K
相关概念视频
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:40Bone Remodeling
38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K