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减肥手术后明显的大脑和神经认知转变:一个试点研究

Bhaswati Roy¹, Mariana Thedim², Chiewlin Liew¹

¹Department of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Frontiers in neuroscience

|November 20, 2024

概括

接受减肥手术的肥胖患者经历了暂时的认知衰退和大脑变化,这些变化在六个月内在很大程度上逆转. 这项研究跟踪了手术前后肥胖个体的认知功能和大脑结构.

科学领域:

神经科学是一个神经科学.
腹部外科手术的结果
在肥胖症中的认知功能

背景情况:

肥胖与较差的手术结果和手术前期神经认知障碍 (PND) 的风险增加有关.
了解大脑对减肥手术 (BS) 的反应对于管理PND至关重要.
这项研究调查了接受BS的肥胖患者的认知轨迹和结构性大脑变化.

研究的目的:

详细介绍接受减肥手术的患者的认知变化.
用MRI绘制与PND相关的结构性大脑变化图.
探索大脑脆弱性,手术和PND之间的关联.

主要方法:

一项前性试点研究,涉及纵向认知评估和MRI.
计划接受BS的19名肥胖患者与50名健康对照进行了比较.
评估发生在手术前,手术后48小时内,并在六个月的随访后.

主要成果:

肥胖患者表现出先前存在的大脑组织变化和较低的认知评分 (MoCA 26) 与对照组 (MoCA 28).
手术导致了进一步的灰质变化,并在手术后立即降低了认知分数 (MoCA 24).
在六个月内,大多数大脑变化逆转,认知得分恢复到基线水平.

结论:

减肥手术在肥胖患者中暂时恶化了大脑结构完整性和认知功能.
观察到与特定认知领域相关的脑损伤.
大多数这些手术诱导的变化在手术后的六个月内是可逆的.

关键词:

减肥手术减肥手术是什么认知功能障碍认知功能障碍磁共振成像技术的使用神经心理测试神经心理测试肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖在外科手术期间出现的神经认知障碍.术后妄症术后妄症手术手术手术手术手术手术手术

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