关于大麻使用对心血管的影响的综述
Shereif H Rezkalla1, Robert A Kloner
1Author Affiliations: Marshfield Clinic Research Institute, Marshfield, Wisconsin (Dr Rezkalla); Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, California (Dr Kloner); and Cardiovascular Division, Dept. of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California (Dr Kloner).
Journal of cardiopulmonary rehabilitation and prevention
|November 20, 2024
概括
大麻使用可能会增加心血管事件,特别是心肌梗塞和脑血管事件,特别是与其他危险因素相结合时. 迫切需要更多的研究来证实这些发现.
科学领域:
- 心血管科学 心血管科学
- 药理学 药理学是指药理学的学科.
- 大麻素研究 研究 大麻素研究
背景情况:
- 大麻素与包括心血管系统在内的各种组织中的大麻素受体 (CB1和CB2) 相互作用.
- 虽然内分泌素效应最小,但外源性大麻使用可以通过CB1受体刺激导致内皮功能障碍和血栓形成.
- CB2受体可能提供一种保护性抗炎反应.
研究的目的:
- 审查有关大麻使用心血管影响的现有文献.
- 确定大麻消费与心血管事件 (CVE) 之间的关联.
- 强调需要进一步研究大麻对心血管健康的影响.
主要方法:
- 在过去20年里,PubMed上发表的综合文献综述研究.
- 重点是最近关于大麻和心血管系统的报道.
- 分析的重点是确定大麻使用与心血管结果之间的联系.
主要成果:
- 大麻使用似乎不会加速动脉样硬化.
- 大麻使用与心肌梗塞风险增加之间存在潜在的联系,特别是在男性使用者中.
- 大麻使用可能会增加脑血管事件,当与烟草使用等危险因素相结合时.
- 发现大麻使用与外周血管疾病之间存在关联.
结论:
- 缺乏关于大麻使用和心血管事件 (CVE) 的确切数据.
- 进一步的前性,受控研究对于确定大麻使用和CVE之间的因果关系至关重要.
- 研究应该集中在医疗或娱乐大麻使用后经历CVE的患者身上.
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