InterPro:2025年的蛋白质序列分类资源
Matthias Blum1, Antonina Andreeva1, Laise Cavalcanti Florentino1
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Nucleic acids research
|November 20, 2024
概括
作为蛋白质序列分类资源的InterPro现在集成了更多的AlphaFold结构,并使用人工智能来描述蛋白质家族. 这一更新增强了它对生物研究和数据分析的实用性.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 蛋白质科学 蛋白质科学
背景情况:
- InterPro是将蛋白质序列分为家族的重要资源.
- 它集成了来自多个数据库的预测模型 (签名).
- InterPro对超过2亿个序列进行了注释,广泛覆盖了UniProtKB.
研究的目的:
- 报告InterPro数据库 (101.0版本) 的状态和最近的发展情况.
- 突出数据库,Web界面和软件中的新功能.
- 展示蛋白质家族分类和域预测方面的进展.
主要方法:
- 整合来自各种成员数据库的预测模型.
- 与InterPro条目对比的蛋白质序列的注释.
- 包括对外资源的映射,如基因本体学和AlphaFold.
主要成果:
- InterPro 101.0 版本详细介绍了重要的更新和发展.
- 增加AlphaFold预测的蛋白质结构的整合.
- 使用人工智能增强了蛋白质家族描述.
- 在过去的两年里,创建了超过5000个新的InterPro项目.
- 访问85,000个蛋白质家族和域,并为退休数据库提供档案支持.
结论:
- InterPro继续发展成为蛋白质序列分类的全面资源.
- 最近的更新改善了对蛋白质家族和结构的理解和分析.
- 自由可用的数据,软件和工具支持各种生物研究工作.
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