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Updated: Jun 7, 2025

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KCTD10 p.C124W 变种通过减弱LLPS介导的突触形成来促进精神分裂症

Chenjun Mu1, Pan Liu1, Liang Liu2

  • 1Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.

Proceedings of the National Academy of Sciences of the United States of America
|November 20, 2024
PubMed
概括

一种特定的KCTD10突变通过破坏液体-液体相分离 (LLPS),导致RHOB积累,在小鼠中引起精神分裂症类行为. 针对RHOB可能为KCTD10相关的大脑疾病提供治疗策略.

关键词:
KCTD10 KCTD10 是一个液态液态相分离 (LLPS) 的方法神经精神疾病是一种神经精神疾病.突触异常是突触异常的发生.

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