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Updated: Jun 7, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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化学因子识别和激活XCR1的分子基础

Xuan Zhang1, Roman R Schlimgen2, Stephanie Singh1

  • 1Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.

Proceedings of the National Academy of Sciences of the United States of America
|November 20, 2024
PubMed
概括

研究人员阐明了XCL1化学激素与XCR1结合的结构基础,这种受体对树突细胞激活至关重要. 这一发现为开发向癌症免疫疗法和疫苗提供了新的途径.

关键词:
在XCL1中,XCL1是XCL1.XCR1 是一个 XCR1 的类型.化学因子受体 化学因子受体传统树突细胞亚型1低温电子显微镜 (cryo-EM) 的使用

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