牛乳酸对早产婴儿的食不耐受和肠道透性的影响:一项随机对照试验
Nermeen Ellakkany1,2, Hesham Abdel-Hady3, Ahmed Mahfouz Eita3
1Faculty of Medicine, Horus University - Egypt, Damietta, Egypt. Nermeen.ellakany@gmail.com.
European journal of pediatrics
|November 20, 2024
概括
口服牛乳酸 (LF) 补充剂改善了早产婴儿的食不耐受. 这种干预措施还降低了肠道透性,这是LF组血清松素水平较低所表明的.
科学领域:
- 新生儿科学 新生儿科学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 过早出生 (26-34周妊娠年龄) 的婴儿由于胃肠功能不成熟而面临食不耐受.
- 牛乳酸 (LF) 在治疗食不耐症和败血症方面表现有前途.
- 这项研究调查了LF对早产新生儿食不耐受和肠道透性的影响.
研究的目的:
- 评估口服牛乳液补充剂在患有食不耐症的早产婴儿的疗效.
- 用血清佐努林度来评估LF对肠道透性的影响.
主要方法:
- 一个随机控制的双盲试点研究.
- 招募了60名早产新生儿 (26-34周妊娠年龄) 患有食不耐症.
- 参与者被随机分配,接受牛的LF (100毫克/天) 或安慰剂4周或直到出院.
主要成果:
- 乳二烯组的全肠养速度明显更快 (9 vs. 15天,P=0.001).
- 在研究结束时,乳酸铁素组的血清度显着较低 (3.38对5.49 ng/ml,P=0.04).
结论:
- 口服牛乳酸可以改善早产婴儿的食不耐受.
- 牛LF补充剂与这种人群的肠道透性降低有关.
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