潜在的随机试验抗生素预防皮肤透脏活检
Kensei Yahata1, Kenichi Koga2, Daisuke Hirai3
1Department of Nephrology, Japanese Red Cross Osaka Hospital, 5-30 Fudegasaki-Cho, Tennoji-Ku, Osaka, 543-8555, Japan. kenseiyahata@gmail.com.
Clinical and experimental nephrology
|November 20, 2024
概括
抗生素预防 (AP) 可能在皮肤脏活检 (RB) 后减少感染的临床意义不大. 这项研究发现了最小的活检后感染,表明AP可能会在某些情况下被遗漏.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 医疗程序 医疗程序
背景情况:
- 感染是通过皮肤进行脏活检 (RB) 后的罕见并发症.
- 尽管很少见,但抗生素预防 (AP) 在日本大约60%的医院中进行.
- 对RB的AP的必要性需要调查.
研究的目的:
- 评估通过皮肤脏活检 (RB) 省略抗生素预防 (AP) 的疗效.
- 确定AP是否能显著降低RB后的感染率.
主要方法:
- 一项随机对照试验,涉及6家医院的364名年龄≥15岁的患者.
- 患者接受了静脉注射塞法索林或没有抗生素预防.
- 主要结局:RB后3-4天的尿液培养结果呈阳性;次要结局:30天内发炎,刺伤部位感染 (PSI) 和其他感染.
主要成果:
- 在塞法佐林和没有AP组 (2.9%对5.1%,p=0.416) 之间,在阳性尿液培养上没有统计学上显著的差异.
- 在没有AP的组中发生了一例肌炎病例 (患者进行了尿道导管注射).
- 没有观察到刺伤部位感染 (PSI),二次结果中没有显著的群体间差异.
结论:
- 皮肤后RB感染的发生率是最小的.
- 虽然没有明确证明AP是不必要的,但数据表明其临床意义可能有限.
- 可能需要进一步的评估来确认AP在皮肤透脏活检中的作用.
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