相关实验视频
Updated: Jun 7, 2025
10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
14.3K
粘附性质和病原体抑制阴道衍生的乳酸菌
Alessandra Pino1,2, Kaisa Hiippala3, Aki Ronkainen3
1Department of Agriculture, Food and Environment (Di3A), University of Catania, Santa Sofia Street, 100, 95123, Catania, Italy.
Probiotics and antimicrobial proteins
|November 20, 2024
概括
阴道乳球菌表现出强大的益生菌潜力,抑制病原体和粘附于细胞. 这些发现支持它们在补充剂中用于改善生殖尿路健康.
科学领域:
- 微生物学 微生物学
- 益生菌研究 益生菌研究
- 生殖和尿道健康
背景情况:
- 阴道微生物群在维持生殖尿路健康方面发挥着至关重要的作用.
- 乳酸菌是健康的阴道微生物组的关键组成部分.
- 识别有效的益生菌菌株对于治疗应用至关重要.
研究的目的:
- 选和选择具有显著益生菌性质的阴道乳酸菌株.
- 评估所选菌株的对抗性活性,粘附能力和病原体排位潜力.
- 评估阴道乳酸菌适用于生殖尿道保健补充剂的适用性.
主要方法:
- 从健康的意大利妇女中分离的27种乳酸菌菌株的查.
- 对抗常见病原体的对抗性活动的评估.
- 对人类结肠 (HT-29) 和阴道 (VK2/E6E7) 表皮细胞的附着性的评估.
- 确定病原体的迁移和排除水平.
主要成果:
- 所有测试的乳酸菌都抑制了至少三种病原体.
- 大多数人表现出对Enterobacter cloacae和Pseudomonas aeruginosa的抗菌活性.
- 所有菌株都表现出对HT-29和VK2/E6E7细胞的粘附性 (>1%的粘附性).
- 病原体的排斥率在9-82%之间,病原体的排斥率在1-99%之间.
结论:
- 阴道乳酸菌对病原体具有显著的保护作用.
- 阴道微生物群是识别潜在益生菌菌株的宝贵来源.
- 精选的乳酸菌株显示出开发补充剂以增强生殖尿路健康的前景.
相关概念视频
01:18Surface Membrane Barriers
1.0K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.0K
01:26Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
01:28Antimicrobial Effectiveness
2
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K