牙周炎与中年和老年人的大脑功能障碍相关,具有正常认知能力
Wei Ye1, Yufei Tao2, Wenrui Wang1
1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Journal of periodontology
|November 20, 2024
概括
牙周炎,即使在具有正常认知的个体中,也与大脑功能连接的变化有关. 这表明牙疾病可能是脑损伤和早期阿尔茨海默病预防的危险因素.
科学领域:
- 神经科学是一个神经科学.
- 口腔健康 口腔健康
- 老年学是一门学科.
背景情况:
- 牙周炎越来越被认为是阿尔茨海默病 (AD) 的潜在危险因素.
- 牙周炎对认知正常 (NC) 中年和老年人的大脑功能的影响仍然不清楚.
- 在NC阶段了解这些影响对于预防早期痴呆症至关重要.
研究的目的:
- 调查中年和老年人具有正常认知 (NC) 的内部网络和互联网功能连接 (FC) 的变化.
- 确定不同程度的牙周炎对这一群体大脑功能的影响.
- 探索牙周炎作为大脑损伤和早期AD预防的潜在风险因素.
主要方法:
- 获得了51名NC患者的牙周数据和休息状态功能磁共振成像 (fMRI).
- 使用独立组件分析 (ICA) 和相关性分析进行统计评估.
- 在没有牙周炎,轻度牙周炎和中度至重度牙周炎的组中比较了功能连接模式.
主要成果:
- 在前置默认模式网络 (aDMN),背部注意网络和背部感觉运动网络 (dSMN) 中观察到内部网络FC的差异.
- 中度至严重的牙周炎与改变的互联网FC有关,包括听觉/腹腔注意力网络和aDMN/ salience网络之间的连接性增加.
- 在后置默认模式网络和右前置双牙网络之间发现了降低的FC,改变的FC和牙周指数之间存在显著的相关性.
结论:
- 牙周炎与内部网络和互联网功能连接的变化有关,即使在认知正常的个体中也是如此.
- 这些发现表明牙周炎可能是脑损伤的潜在危险因素.
- 该研究提供了理论见解,并确定了早期预防阿尔茨海默病的潜在新目标.
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