在患有多发性硬化症的人群中调查时间和血管年龄之间的差异
Gorica D Maric1, Tatjana D Pekmezovic1, Olivera S Tamas2,3
1Faculty of Medicine, Institute of Epidemiology, University of Belgrade, Belgrade, Serbia.
PloS one
|November 20, 2024
概括
在患有多发性硬化症 (PwMS) 的人群中,血管年龄 (VA) 与时间年龄 (CA) 显著不同. 诸如BMI,体力活动和2型糖尿病等因素会影响这种差异,突出显示PwMS患者血管风险增加.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 血管医学 血管医学
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 心血管疾病 (CVD) 风险因素在患有多发性硬化症 (PwMS) 的人中很普遍.
- 血管年龄 (VA) 评估可以揭示亚临床动脉样硬化.
研究的目的:
- 在塞尔维亚贝尔格莱德的多发性硬化症 (PwMS) 患者队列中确定血管年龄 (VA).
- 评估PwMS中的时间年龄 (CA) 和VA之间的差异.
- 确定与PwMS中CA和VA之间的差异相关的因素.
主要方法:
- 一项涉及塞尔维亚贝尔格莱德274名PwMS的病例控制研究.
- 根据性别,年龄,吸烟情况,总胆固醇和缩血压计算VA.
- 用于确定与CA-VA差异相关的因素的等级回归分析.
主要成果:
- 在PwMS队列中,在CA和VA之间发现了统计学上显著的差异 (p<0.001).
- 在高脂血症,高血压和2型糖尿病患者的PwMS中,观察到VA和CA-VA差异最高.
- 扩展残疾状况量 (EDSS) 评分,BMI,体力活动和2型糖尿病解释了CA-VA差异的24%.
结论:
- 在PwMS中,CA和VA之间存在显著差异,VA随着动脉样硬化负担的增加而增加.
- 体重指数,体力活动,EDSS和2型糖尿病是导致PwMS中CA-VA差异的关键因素.
- 这些发现强调了在PwMS中管理心血管风险因素的重要性.
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