哺乳动物的脂毒性和卵细胞质量:发病,后果和可逆性
Ben Meulders1, Waleed F A Marei2,1, Lien Loier1
1Gamete Research Centre, Laboratory of Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium; email: ben.meulders@uantwerp.be, waleed.marei@uantwerp.be, lien.loier@uantwerp.be, jo.leroy@uantwerp.be.
Annual review of animal biosciences
|November 20, 2024
概括
代谢压力会增加自由脂肪酸 (FFAs),损害卵子发育和潜在的后代健康. 增强卵子线粒体功能的治疗可以改善妊娠结果.
科学领域:
- 生殖生物学 生殖生物学
- 代谢障碍 代谢障碍 代谢障碍
- 线粒体医学是指线粒体医学.
背景情况:
- 代谢压力会增加血清自由脂肪酸 (FFA),导致非脂肪组织的脂毒性.
- 卵巢卵泡液中FFA的升高会对卵细胞发育产生负面影响.
- 机制包括改变卵细胞代谢,氧化应激和线粒体功能障碍.
研究的目的:
- 调查脂毒性对卵细胞发育和随后的后代健康的有害影响.
- 探索针对卵细胞线粒体功能的潜在治疗策略.
主要方法:
- 使用了体外和体外哺乳动物模型.
- 研究了高FFA对卵细胞代谢,氧化应激和线粒体功能的影响.
- 评估了对早期胚胎发育和表观遗传重编程的影响.
主要成果:
- 高度的FFA会损害卵细胞代谢,增加氧化应激.
- 卵细胞中的线粒体功能障碍导致胚胎中的线粒体有缺陷.
- 这可能会阻碍表观遗传重编程,损害早期发育,影响后代的健康.
结论:
- 脂毒性对卵细胞质量和胚胎发育构成重大威胁.
- 缺陷的线粒体可能会持续存在,影响长期后代的健康.
- 开发增强卵细胞线粒体功能的治疗方法对于改善代谢应激个体的生殖结果至关重要.
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