伪酶STK40通过准FOXO转录因子来促进TH1和TH17细胞的分化

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Updated: Jun 7, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

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Yuexiao Tao1, Zhenyan Jiang1, Huizi Wang1

  • 1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine; Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine; and Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Science advances
|November 20, 2024
PubMed
概括

伪酶STK40通过降解FOXO1/4.4促进T助手1/17细胞在自身免疫性疾病中的分化. 抑制STK40可能为炎症和自身免疫性疾病提供新的治疗方法.

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