对34种常规化学分析物的毛细血管指针和静脉血液采样进行比较:在医院和远程血液采样的潜力
Martijn J H Doeleman1,2, Anne-Fleur Koster1,2, Anouk Esseveld1,2
1Pediatric Immunology and Rheumatology, Division of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands.
Clinical chemistry and laboratory medicine
|November 20, 2024
概括
毛细血管血液样本与静脉血液密切匹配,用于大多数常规化学测试. 这一发现支持毛细血管血液采集作为一种可行的替代方案,有可能改善患者的舒适度,并使远程自取样能够实现.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 诊断测试 诊断测试 诊断测试
背景情况:
- 静脉血液采样是常规化学分析的标准.
- 毛细血管血液采样在患者的舒适性和可访问性方面提供了潜在的优势.
- 静脉和毛细血管样本之间的可比性数据对于验证替代方法至关重要.
研究的目的:
- 为了评估测量静脉与毛细血管血液样本中的常规化学分析物的可比性.
- 根据已确定的质量标准 (TEa和CLIA 2024) 评估毛细血管血液采样的适用性.
主要方法:
- 从成年患者收集了静脉和毛细血管血液样本.
- 使用西门子Atellica® CH或IH分析仪分析了33种常规化学分析物的综合面板.
- 德明回归和平均相对差异与允许总误差 (TEa) 和CLIA 2024标准进行了比较.
主要成果:
- 在大多数分析样品中,静脉和毛细血管样本之间观察到很好的可比性.
- 在33个分析结果中,有30个符合理想的允许总错误 (TEa) 标准.
- 根据CLIA 2024标准对29种分析物进行了评估,葡萄糖是唯一不符合建议限制的分析物.
结论:
- 毛细血管血液采样是大多数常规化学分析物的静脉采样的一个合适的替代方案.
- 这些发现支持使用毛细血管血液采集,这可以增强患者的体验,并促进远程自取样.
- 虽然一般可以比较,但像葡萄糖这样的特定分析剂需要根据CLIA 2024标准进行进一步评估.
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