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在精神分裂症患者和持续的听觉口头幻觉的精神分裂症患者中,皮层下灰质中的自由水成像

Jinguang Li¹, Jingqi He², Honghong Ren³

¹Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Psychiatry, Wuhan Mental Health Center, Wuhan, China.

Schizophrenia research

|November 20, 2024

概括

皮下灰质 (SGM) 异常,特别是双边尾状质,与精神分裂症的听觉语言幻觉 (AVH) 有关. 自由水和微观结构变化,而不是体积,是AVH严重程度的关键指标.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
放射学放射学是一门学科.

背景情况:

皮下灰质 (SGM) 在精神分裂病理生理学中起着作用,特别是听觉语言幻觉 (AVH).
关于与AVHs相关的SGM中细胞外自由水 (FW) 和白质微观结构的研究有限.

研究的目的:

为了研究具有和没有AVH的精神分裂症患者的SGM中的宏观体积,FW和白质微观结构.
为了确定与持续性AVH (p-AVH) 相关的SGM异常及其与症状严重程度的相关性.

主要方法:

利用自由水消除技术来评估FW和白质微观结构.
在60名患有p-AVH的精神分裂症患者,36名没有AVH史的患者 (n-AVH) 和43名健康对照 (HC) 中进行了SGM比较.
在SGM区域分析了宏观体积,FW和微观结构完整性.

主要成果:

与对照组相比,在精神分裂症患者组中没有发现宏观体积异常.
在精神分裂症患者的多个SGM结构中检测到FW和白质微观结构的异常.
与p-AVH组不同的是,p-AVH组在双边尾状体中显示出显著的FW和微观结构异常,与AVH严重程度相关,与n-AVH组不同.

结论:

在SGM中,FW和微观结构异常比精神分裂症的体积变化更为突出,无论AVHs.
双边尾状体与AVHs的病理生理学有关.
双边尾状体中正常的FW和微观结构可能是精神分裂症患者没有AVH史的特征.

关键词:

免费水域成像成像技术持续的听觉语言幻觉.精神分裂症是一种精神分裂症.下皮层灰色物质是什么?

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