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一种绿色分析方法,用于同时确定兽医配方中的甲酸和普雷迪尼索隆酸,使用紫外线光谱和缩小尺寸算法

Marwan A Ibrahim¹, Ayman M Algohary², Youssef O Al-Ghamdi³

¹Department of Biology, College of Science Al-zulfi, Majmaah University, Al-Majmaah 11952, Saudi Arabia; Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo 11566, Egypt.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

|November 20, 2024

概括

这项研究引入了一种新的,环保的紫外线光谱法,与尺寸缩小算法相结合,用于精确测量兽医药中的甲基甲酸 (DXM) 和甲基甲酸 (PRD),提高效率和可持续性.

科学领域:

分析化学分析化学
药品分析药品分析
绿色化学绿色化学

背景情况:

准确量化兽药对于动物健康至关重要.
甲酸 (DXM) 和普雷迪尼索隆 (PRD) 是兽医中广泛使用的抗炎性皮质糖类药物.
现有的分析方法可能缺乏效率,成本效益或环境可持续性.

研究的目的:

开发和验证一种新的,具有成本效益和环境可持续的分析方法,用于在兽医配方中同时量化DXM和PRD.
为此分析任务评估各种维度减小算法 (DRA) 的性能.
评估开发方法的生态影响和绿色性.

主要方法:

使用紫外线光谱学与十七种不同的DRA相结合的同时量化.
使用MSE,MAE,MedAE和R2.2等指标对DRA的性能评估.
通过使用GSST,NEMI,Eco-Scale,碳足迹和MoGAPI等工具的准确性概况和生态评估来验证方法.

主要成果:

迷你批次稀少主要成分分析显示,在评估的DRA中,预测准确度更高.
开发的方法表现出令人满意的准确性和更绿色的形状,碳足迹低 (0.0006公斤CO2eq/样本).
与HPLC的统计比较显示没有显著差异,证实了方法的可靠性.

结论:

紫外光谱和DRAs的协同组合为制药分析提供了显著的进步.
提出的方法是准确的,高效的,具有成本效益的,环境可持续的,用于确定DXM和PRD度.
这种方法增强了药物分析,同时促进了兽医中更绿色的分析实践.

关键词:

绿色分析方法绿色分析方法主要组件分析主要组件分析合成葡萄糖皮质类药物紫外线光谱法紫外线光谱法

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