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开发和验证一种分析方法,以同时量化口服悬浮剂中的Posaconazole Form I和Form-S

Michail Lykouras1, Christos Kontoyannis2, Malvina Orkoula3

  • 1Institute of Chemical Engineering Sciences, Foundation of Research and Technology-Hellas (ICE-HT/FORTH), Platani, Achaias GR-26504, Greece.

Journal of pharmaceutical and biomedical analysis
|November 20, 2024
PubMed
概括

口服悬浮中的多态形式的波萨可纳可能会影响药物的疗效和安全性. 使用旋转系统的拉曼光谱准确量化了S型和I型的共存,克服了以前的分析挑战.

关键词:
在PLS回归过程中,回归多态性多态性多态性波萨可纳 (Posaconazole) 是一种可靠的药物.量化 量化 量化 量化拉曼光谱法 拉曼光谱法固态硬件是一种固态硬件.暂停 暂停 暂停

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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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