描述粉样蛋白形成过程中的异质性

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Updated: Jun 7, 2025

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
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Hoi Sung Chung1

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA.

Current opinion in structural biology
|November 20, 2024
PubMed
概括

了解蛋白质聚合,这是疾病的关键因素,需要描述其复杂的途径. 新的方法正在改善我们对粉样蛋白形成及其中间体的理解.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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