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在多克索鲁比诱导的毒性和潜在的治疗药物中的分子信号通路
Changxu Lu1, Jinwen Wei2, Can Gao2
1College of Exercise and Health, Shenyang Sport University, Shenyang, Liaoning, China; Department of Urology, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Shenyang, Liaoning, China.
International immunopharmacology
|November 20, 2024
概括
多克索鲁比 (DOX) 化疗会通过活性氧物种 (ROS) 引起损伤 (毒性). 本综述详细介绍了DOX诱导的毒性途径以及新药开发的潜在治疗点.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学 是一个学科.
背景情况:
- 多克索鲁比 (DOX) 是各种癌症的重要化疗剂.
- 由于严重的毒性,特别是心脏毒性和毒性,DOX的临床使用受到限制.
- DOX诱导的毒性 (DIN) 缺乏有效的治疗方法,并引起了重大的临床关注.
研究的目的:
- 审查DIN.中涉及的分子机制和信号通路.
- 确定潜在的治疗剂和减轻DIN的目标.
- 为开发针对DOX诱导的损伤的新策略提供参考.
主要方法:
- 对多克索鲁比诱导的毒性研究的文献综述.
- 对分子机制的分析,包括反应性氧物种 (ROS) 的作用.
- 确定和总结关键的信号通路 (例如AMPK,JAKs/STATs,MAPK,Nrf2/ARE,NF-κB,PI3K/AKT) 和调节剂.
主要成果:
- 反应性氧物种 (ROS) 是DIN的核心,启动亡,炎症和纤维化.
- 多个信号通路,包括AMPK,JAKs/STATs,TRPC6/RhoA/ROCK1,YAP/TEAD,SIRTs,Wnt/β-catenin,TGF-β/Smad,MAPK,Nrf2/ARE,NF-κB和PI3K/AKT,都参与了DIN.
- 已经确定了针对这些途径的各种潜在治疗剂.
结论:
- 了解DIN分子通路对于开发有效治疗方法至关重要.
- 针对特定的途径为针对DOX诱导的脏损伤的新型治疗干预提供了希望.
- 本综述为DIN.的未来研究和药物开发提供了一个全面的资源.
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