基本震患者的步态和平衡功能障碍与白质相关
Swati Parida1, Anand Kumar1, Ashish Verma2
1Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
概括
基本震 (ET) 涉及运动和非运动症状. ET患者的步行和平衡问题与大脑中的白质变化相关,这表明神经解剖学的基础.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 运动障碍 运动障碍
背景情况:
- 基本震 (ET) 呈现出运动症状,如震,步态和平衡功能障碍.
- 在ET中,非运动特征包括认知缺陷,抑郁症和睡眠障碍.
研究的目的:
- 临床特征步态和平衡功能障碍在基本震 (ET) 患者.
- 通过扩散张力成像 (DTI) 来研究ET中步态和平衡障碍的大脑局部.
主要方法:
- 174名ET患者和150名对照患者接受了神经心理测试和步态评估.
- 扩散张力成像 (DTI) 分析了白质完整性 (平均扩散性,分数异构性).
- ET诊断遵循了运动障碍学会的标准.
主要成果:
- 与对照组相比,ET患者在平衡和步行得分上表现出显著的差异.
- 在ET中走路不佳的得分与大脑白质中的DTI指标变化相关.
- 在25%的ET患者中发现认知障碍.
结论:
- 基本震中的行走障碍具有神经解剖学基础.
- 在ET患者中,DTI指标与步行功能障碍相关.
- 这项研究强调了白质变化与ET运动缺陷之间的联系.
相关概念视频
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Equilibrium and Balance
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
Disorders of Acid-Base Balance
The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Prosopagnosia
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
Traumatic Brain Injury l: Introduction
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...


