ABO基因多态化和COVID-19严重程度:对血液学并发症,炎症标志物和肺部病变的影响
Mohammad Samet1, Parvane Raeesi Mahdiabadi1, Masoud Tajamolian2
1Departments of Internal Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Human immunology
|November 20, 2024
概括
ABO基因变体rs657152显著影响伊朗患者的COVID-19严重程度,影响血液标记物和肺部损伤. AC基因型似乎具有保护性,而CC基因型与更糟糕的结果有关.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 传染性疾病 传染性疾病
- 医学研究 医学研究
背景情况:
- 在患者之间,COVID-19的严重程度有很大差异.
- 人们越来越认识到遗传因素会影响疾病的结果.
- ABO基因是调节COVID-19严重性的潜在候选者.
研究的目的:
- 为了调查ABO基因内部变异rs657152和COVID-19严重程度之间的关联.
- 分析这种变种对临床症状,血液学参数,炎症标志物和肺病变的影响.
- 确定ABO多态性在疾病进展和患者结局中的作用.
主要方法:
- 在240名COVID-19患者中使用tetra-ARMS PCR对ABO多态的基因定型 (rs657152).
- 将患者分为门诊患者,病房住院患者和重症监护室患者的分类.
- 通过CT扫描评估炎症标志物 (CRP,ESR),全血细胞计 (CBC) 和肺病变严重程度.
主要成果:
- 在临床严重程度组 (p < 0.003) 中观察到ABO等位基因频率和基因型比例的显著差异.
- ABO多态性与C反应蛋白 (CRP) 水平有显著的关联,但与红细胞沉率 (ESR) 没有显著的关联.
- 在 ABO 多态,肺病变严重程度和临床分类之间发现了显著的相关性.
结论:
- 在伊朗患者中,ABO基因变异rs657152与COVID-19严重程度有很大关系.
- 这种多态性影响了血液学并发症,炎症反应和肺损伤的程度.
- AC基因型显示出保护作用,而CC基因型与更严重的临床表现有关.
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