延迟服用德诺苏马布与骨折风险增加的关联:基于人口的回顾性研究
Kyoung Min Kim1, Seol A Jang1, Nam Ki Hong2
1Division of Endocrinology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
Endocrinology and metabolism (Seoul, Korea)
|November 20, 2024
概括
延迟服用德诺苏马布会增加骨折的风险,即使是短暂的延迟1-3个月. 坚持规定的德诺苏马布剂量计划对于骨质疏松症管理和骨折预防至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 德诺苏马布的骨重塑抑制在停止治疗后是可逆的.
- 了解与延迟服用登苏马布相关的骨折风险至关重要.
研究的目的:
- 调查延迟使用登苏马布与骨折风险之间的关联.
- 根据剂量延迟的持续时间来量化骨折风险增加的程度.
主要方法:
- 在全国范围内对45-89岁的女性进行了数据分析,这些女性开始接受骨质疏松症的德诺苏马布治疗.
- 参与者的分层基于denosumab剂量间隔:早期 (ED30),按时 (参考) 和延迟 (DD90,DD180,DD181+).
- 主要结局:所有临床骨折的发生率,包括脊椎骨折.
主要成果:
- 总共分析了149,199名参与者,报告了2,323例临床骨折.
- 推迟用药1-3个月 (DD90) 显著增加了整体骨折发生率 (HR 1.2).
- 较长的延迟 (DD180,DD181+) 显示骨折风险大幅增加 (HR分别为1.9和1.8),与脊椎骨折一致.
结论:
- 延迟使用德诺苏马布剂量,即使延迟1至3个月,也与骨折风险的增加有显著联系.
- 骨折的风险随着德诺苏马布的更长的延迟而升级.
- 强调遵守德诺苏马布剂量计划对于有效治疗骨质疏松症和预防骨折至关重要.
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