在LDHB缺乏的神经元中乳酸利用率降低导致长期记忆保留受损
Jin Soo Lee1, Bok Seon Yoon2, Songmi Han3
1Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, South Korea; Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.
Experimental neurology
|November 20, 2024
概括
乳酸脱酶B (LDHB) 缺乏通过减少神经元乳酸利用来损害长期记忆. 这挑战了天体细胞-神经元乳酸穿假说,揭示了灵活的神经元代谢.
科学领域:
- 神经科学是一个神经科学.
- 细胞的新陈代谢
- 生物化学 生化学
背景情况:
- 神经元需要大量的能量来运作,依赖于高效的代谢途径.
- 天体细胞-神经元乳酸穿 (ANLS) 假设神经元优先利用天体细胞衍生的乳酸而不是葡萄糖.
- 乳酸脱酶B (LDHB) 对于将乳酸转化为酸盐至关重要,这是乳酸利用的关键步骤.
研究的目的:
- 研究乳酸脱酶B (LDHB) 在神经元能量代谢中的作用.
- 确定LDHB缺乏对认知功能,特别是记忆力的影响.
- 检查LDHB功能对星细胞-神经元乳酸穿 (ANLS) 假设的影响.
主要方法:
- 在培养中研究LDHB缺乏的神经元,以评估能量代谢.
- 对缺乏LDHB的小鼠大脑进行了乳酸积累和神经病理学分析.
- 在LDHB缺乏的小鼠中评估了长期和短期记忆性能.
- 研究了乳酸脱酶A (LDHA) 在LDHB缺陷神经元中的存在和活性.
主要成果:
- 缺乏LDHB的神经元表现出乳酸驱动的能量代谢减少和大脑乳酸积累增加,表明乳酸利用受损.
- LDHB 缺乏与长期记忆的缺陷相关,而不是短期记忆.
- 在LDHB缺乏的小鼠中,神经病理只受到轻微的影响.
- 缺乏LDHB的神经元在葡萄糖条件下保持稳定的能量代谢,这表明了其他代谢途径或LDH活性.
结论:
- 神经LDHB对于高效的乳酸利用和长期记忆形成至关重要.
- 这项研究挑战了大脑中LDH异型体的严格细分.
- 研究结果表明,神经元的新陈代谢概况比ANLS假设提出的更为灵活,LDHA在神经元能量平衡中可能发挥作用.
更多相关视频
相关概念视频
01:03Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K
01:35Long-term Potentiation
54.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.8K
01:22Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
01:24Muscle Recovery and Fatigue
2.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.0K
01:23Role of Neurotransmitters in Memory
436
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
436