早期青春期内化问题的多模式大脑年龄指标:一个纵向的调查
Niamh MacSweeney1, Dani Beck1, Lucy Whitmore2
1PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway; Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|November 20, 2024
概括
青春期早期大脑年龄差距的增加与女性更高的内化问题有关. 这项纵向研究强调了青少年大脑发育和心理健康脆弱性的潜在性别差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 青少年心理健康 青少年心理健康
背景情况:
- 青春期是内化问题出现的关键时期,女性表现出更高的脆弱性.
- 纵向研究很少,这限制了我们对大脑成熟的个体差异如何与青春期内化问题的理解.
研究的目的:
- 研究多模式大脑年龄与青少年内化问题之间的纵向关联.
- 探索大脑年龄差异变化和内化问题的关系中的潜在性别差异.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究的数据,包括T1加权成像,扩散张力成像和静止状态功能性MRI.
- 大脑年龄模型在基线 (平均年龄9.9岁) 和2年随访 (平均年龄11.9岁) 时在一个大队列 (n>8000) 上被开发和验证.
- 在3年随访 (平均年龄为12.9岁) 时,使用简要问题监测器评估了内化问题.
主要成果:
- 在基线和随访期间,大脑年龄差距 (BAG) 的增加与女性3年随访时的内化问题有关,但男性并非如此.
- 这种关联对于T1加权成像和静止状态功能性MRI数据是显著的,但不是扩散张力成像.
- 即使在控制先前的内部化问题之后,这些发现仍然很重要.
结论:
- 青春期早期大脑年龄差距的较大增加可能表明女性年轻人对内化问题的脆弱性增加.
- 需要进一步的纵向研究来确定 BAG 的增加是否意味着加速的大脑发育及其对内化问题轨迹的影响.
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