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Updated: Jun 7, 2025

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method
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Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Published on: May 18, 2018

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酸盐和二碳酸盐缓冲溶液作为溶解试验介质的比较,用于预测febuxostat配方的生物等价性

Masaki Higashino1,2, Kiyohiko Sugano1

  • 1Molecular Pharmaceutics Lab., College of Pharmaceutical Sciences, Ritsumeikan University.

Chemical & pharmaceutical bulletin
|November 20, 2024
PubMed
概括

与酸盐缓冲剂 (PPB) 相比,二碳酸盐缓冲剂 (BCB) 在10mM和25rpm的速度更好地预测立即释放 (IR) 的febuxostat配方的生物等价性 (BE). 这一发现增强了药物产品开发的溶解测试.

关键词:
碳酸二氧化碳的使用方法生物等价性 生物等价性生物相关的生物相关.浮动盖子 浮动盖子在体外体内相对应的相关性

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