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暴露时间对人类压力诱导的炎症反应的影响:道工人和水下潜水员之间的比较
Zuha Imtiyaz1, Owen J O'Neill2,3, Douglas Sward1
1Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Physiological reports
|November 20, 2024
概括
与潜水员相比,暴露于高压的道工人显示炎症标志物和中性粒细胞激活的增加. 更长的暴露时间,而不仅仅是压力,可能会驱动这些反应,可能会影响减压疾病的病理生理学.
科学领域:
- 环境和职业健康 环境和职业健康
- 人体生理学 人体生理学
- 生物医学科学 生物医学科学
背景情况:
- 人类对长时间的非水生高压暴露的反应还未得到充分研究.
- 与水下潜水员相比,道建设工人面临着独特的高压环境.
- 了解这些差异可能会阐明解压力疾病 (DCS) 的病理生理学.
研究的目的:
- 研究道工人的炎症反应与高压条件下的潜水员相比.
- 为了比较血液中微粒 (MP) 水平,MP内介质素 (IL-1β),血凝索林 (pGSN) 和中性粒细胞激活标记物.
- 为了确定暴露时间对这些生理标志物的影响.
主要方法:
- 分析了15名道工人和8名潜水员的血液样本.
- 暴露条件:道工人 (142-156kPa,4.1-4.9小时),潜水员 (149kPa,0.61小时).
- 对MPs,IL-1β,pGSN和中性粒细胞激活标记物的测量 (CD66b+,CD18,髓氧化酶,CD41).
主要成果:
- 血液微粒 (MPs) 和MP内部IL-1β的类似升高,以及血凝素 (pGSN) 的降低在两组中都被观察到.
- 与潜水员相比,道工人表现出明显增加的循环CD66b+中性粒细胞和细胞激活标志物.
- 中性粒细胞活化随着更长的暴露时间而增加,这表明依赖时间的炎症反应.
结论:
- 血液微粒 (MP) 的升高在压力暴露期间迅速发生,在几分钟内达到稳定状态.
- 中性粒细胞的激活需要显著更长的高压暴露时间.
- 长时间的压力暴露,如道工人所经历的那样,可能会导致更大的炎症反应,与减压疾病相关.
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