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Updated: May 2, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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对IO-108,一种抗LILRB2抗体的I阶段剂量升级研究,在患有晚期固体瘤的患者中进行

Matthew H Taylor1, Aung Naing2, John Powderly3

  • 1Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA xiaomin.schebye@immuneonc.com matthew.taylor@providence.org.

Journal for immunotherapy of cancer
|November 20, 2024
PubMed
概括

一种新型抗体IO-108在先进的固体瘤中显示出安全性和有效性. 用IO-108针对LILRB2可能会增强抗PD-1疗法,在癌症治疗中显示出潜在的潜力.

关键词:
生物标志物生物标志物免疫调节器 免疫调节器免疫治疗是一种免疫疗法.单克隆抗体是一种单克隆抗体.固体瘤是一个固体瘤.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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