与饮食模式相关的血代谢物概况:探索与结直肠瘤风险的关联
Jingjing Ni1, Haojie Lu1, Weiyi Chen1
1Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P.R. China.
European journal of nutrition
|November 20, 2024
概括
特定的饮食模式及其相关代谢物概况显著降低结直肠瘤风险. 代谢物概况起到关键的调解作用,为结直肠癌预防策略提供了新的途径.
科学领域:
- 营养流行病学 营养流行病学
- 代谢学 代谢学 代谢学
- 癌症研究 癌症研究
背景情况:
- 饮食模式与结直肠癌 (CRC) 和腺瘤的发展有关.
- 血代谢物概况在这种关系中的调解作用仍然不清楚.
研究的目的:
- 调查饮食模式与结直肠瘤风险之间的关联.
- 探索血代谢物概况在这种协会中的调解作用.
主要方法:
- 分析了95,275名英国生物库参与者的血代谢和饮食数据.
- 用弹性净回归估计14种饮食模式的代谢物概况得分.
- 考克斯回归分析以评估关联和调解效应.
主要成果:
- 五种饮食模式 (WCRF,CRC得分,AHEI-2010,DASH,hPDI) 与大肠直肠瘤风险降低有关.
- 这五种模式的代谢物概况得分也显示了与风险的反向关联.
- 代谢物概况介于饮食和结直肠瘤风险之间的影响的6.37%至27.23%.
结论:
- 特定的饮食模式及其代谢物概况与结直肠瘤风险相反相关.
- 代谢物概况可能会调解饮食和结直肠瘤风险之间的联系.
- 结果为结直肠癌/腺瘤预防和未来研究提供了洞察力.
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