自然产品和肠道微生物群在瘤免疫治疗中的潜力
Luchang Cao1, Xinmiao Wang1, Xinyi Ma1
1Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5, Beixian'ge Street, Xicheng District, Beijing, China.
Chinese medicine
|November 20, 2024
概括
自然产品可以通过调节肠道微生物群来增强抗瘤免疫疗法. 本综述探讨了对免疫疗法的微生物耐药性和可能改善各种癌症治疗疗效的天然化合物.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫疗法为癌症治疗提供了一种新的方法,但在患者的反应率方面面临着挑战.
- 对抗瘤免疫疗法的耐药性是实现大多数患者和癌症类型理想治疗结果的重要障碍.
研究的目的:
- 探索抗瘤免疫疗法耐药性的病原性.
- 识别与免疫疗法耐药性和疗效相关的天然产品和微生物因素.
主要方法:
- 对肠道微生物群和微生物代谢物在免疫疗法耐药性中的作用现有文献的综述.
- 对调节微生物群以增强抗瘤免疫治疗的天然产品和传统中医药的分析.
主要成果:
- 特定的肠道细菌 (例如,Fusobacterium nucleatum,Akkermansia muciniphila) 和它们的代谢物与抗瘤免疫疗法的耐药性有关.
- 通过调节微生物群,各种天然产品 (例如,百花素,人参,光泽) 显示出提高免疫疗法的效率的潜力.
结论:
- 天然产品是克服恶性瘤免疫疗法耐药性的有希望的策略.
- 需要进一步的研究来澄清天然产品在不同癌症和免疫抵抗情景中的应用,特别是胰腺,食道和胃恶性瘤.
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