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在UPSIDE怀孕队列中,尿道菌雌激素和妊娠体重增加

Carolyn W Kinkade¹, Zorimar Rivera-Núñez^1,2, Anita Brinker¹

¹Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road Piscataway, 08854, Piscataway, NJ, USA.

Environmental health : a global access science source

|November 20, 2024

概括

暴露于常见的真菌毒素泽拉伦 (ZEN) 的孕妇经历了更大的妊娠体重增加 (GWG). 这项研究突出了怀孕期间菌雌激素暴露的潜在风险.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
流行病学流行病学

背景情况:

泽拉伦 (ZEN) 是一种在食物中普遍存在的真菌毒素,通过与雌激素受体结合,充当真菌雌激素.
尽管广泛暴露和已知的生殖效应,流行病学研究ZEN在怀孕期间的影响是有限的.
合成的菌雌激素Zeranol被用作牛的生长促进剂.

研究的目的:

在孕妇中调查泽拉伦 (ZEN) 暴露与妊娠期体重增加 (GWG) 之间的关联.
探索ZEN代谢物和GWG之间的关系.
检查胎儿性别对潜在效果的改变.

主要方法:

从286名孕妇参与者身上收集了三个月的尿液样本.
使用HPLC和高分辨率联质谱法量化了ZEN及其代谢物和其代谢物总量 (mycoestrogens).
纵向模型分析了菌雌激素水平与总GWG和GWG率之间的关联.

主要成果:

在超过93%和95%的样本中分别检测到ZEN和菌雌激素.
菌雌激素暴露与总GWG和GWG率有积极的关联.
在携带男性胎儿的参与者中,相关性更强,并且独立于饮食因素.

结论:

怀孕期间暴露于 Estrogen 可能与增加妊娠期体重增加有关.
需要进一步的研究来阐明下游对母亲和婴儿健康的影响.
这项研究提供了关于ZEN暴露在怀孕期间对健康的影响的流行病学证据.

关键词:

内分泌破坏性化学物质破坏内分泌的化学物质.怀孕期间体重增加.这些是mycoestrogens.怀孕怀孕怀孕怀孕泽拉伦没有一个.

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