血清学上活跃的临床静止性狼性炎患者的短期增量普得尼松治疗:一项回顾性观察性研究
Ning An1, Hao-Tao Chen1, Wen-Bo Deng1
1Department of Nephrology, National Clinical Key Specialty Construction Program (2023), Institute of Nephrology, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, 57 Renmin Road, Zhanjiang, 524001, Guangdong, China.
短期增量普雷尼松疗法有效降低狼性炎 (LN) 复发在患者有活跃的血清学,但静止疾病. 这种方法是安全的,与标准护理相似的不良事件率,使其成为管理LN的有价值选择.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 狼性炎 (LN) 是系统性红斑狼的一个严重表现.
- 管理血清活跃,临床静止的LN需要策略来防止复发而不会增加不良事件.
- 普雷尼松是一种常见的治疗方法,但在这种特定的临床场景中,其最佳使用是有争议的.
研究的目的:
- 评估短期增量普得尼松疗法的疗效和安全性,以预防血清活跃,临床静止的LN患者的复发.
- 为了比较接受增量普得尼松和接受标准维持治疗的患者之间的复发率和不良事件.
主要方法:
- 对153名血清活跃,临床静止的LN患者进行了回顾性审查.
- 患者被分为对照组 (标准维护) 和前尼松增量组 (额外的前尼松高达10毫克/天,逐渐减少3个月).
- 在18个月的随访期间,分析了狼活动,干扰和不良事件.
主要成果:
- 与对照组相比,普德尼松增量组的复发率 (5.2%与25.3%,P=0.002) 和脏复发率 (P=0.013) 显著降低.
- 两组之间没有观察到不良事件的显著差异;感染是两组的主要不良事件.
- 在预尼松增量组中,观察到较低的血清补充C3水平.
结论:
- 短期增量普得尼松疗法是一种安全有效的策略,可降低血清活跃,临床静止性狼性炎患者的复发率.
- 这种治疗方法为管理这种特定的LN患者群体提供了有利的风险效益概况.
- 增量普得尼松可以被认为是治疗静止性狼性炎的宝贵工具,以防止疾病爆发.
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