确定因肥胖而调整的氧沙的最佳剂量量
Gregory W Roberts1, Viviane De Menezes Caceres2, Anthony Damiani3
1SA Pharmacy, Southern Adelaide Local Health Network, Adelaide, South Australia, Australia.
British journal of clinical pharmacology
|November 21, 2024
概括
对于肥胖患者来说,以诺沙林的剂量是具有挑战性的. 理想体重+40% (IBW+40%) 或瘦体重+40% (LBW+40%) 显示出比实际体重更好的抗Xa水平,因此需要进一步研究.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药物的剂量 药物的剂量
背景情况:
- 肥胖症中的埃诺沙巴林剂量是复杂的,目前的方法使用实际体重 (ABW) 或理想体重 (IBW),可能导致治疗水平低于最佳水平或增加出血风险.
- 确定以体重为基础的西剂量最佳指标对于改善患者的治疗结果至关重要,尤其是在肥胖患者中.
研究的目的:
- 为了确定最佳的肥胖度调整后的埃诺沙巴林剂量重量指标.
- 为了比较不同基于体重的素剂量指标与肥胖和不肥胖的患者的抗Xa水平之间的关联.
主要方法:
- 对220名每天两次服用埃诺沙巴林的患者进行了回顾性分析.
- 抗Xa因子水平在剂后3-5小时被测量. 多重线性回归分析了名义剂量权重 (IBW,LBW,ABW和调整的百分比) 和抗Xa水平之间的差异,控制功能.
主要成果:
- 对于体重指数 (BMI) ≥30 kg/m2的患者来说,IBW+40%和LBW+40%解释了抗Xa水平的最大变异 (23%).
- 实际体重 (ABW) 与抗Xa水平 (18%) 的相关性最低,其次是未调整的IBW (13%) 和未调整的LBW (19%).
- 在BMI<30 kg/m2的患者中,IBW+20-50%和LBW+10-40%显示了类似的变异 (21%).
结论:
- 使用IBW+40%或LBW+40%的埃诺沙巴林剂量可能会在肥胖患者中提供比ABW,IBW或LBW更一致的抗Xa反应.
- 这些调整后的体重指标需要进一步调查,因为在肥胖人群中,沙剂量策略的潜在改进.
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