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可重现的路线:可靠地导航连接体,以丰富个性化的脑刺激策略

Yilin Liu¹, Mark H Sundman¹, Chidi Ugonna²

¹Brain Imaging and TMS Laboratory, Department of Psychology, University of Arizona, Tucson, AZ, United States.

Frontiers in human neuroscience

|November 21, 2024

概括

结构连接 (SC) 引导的准对于规划非侵入性脑刺激 (NIBS) 治疗,如重复性跨磁刺激 (rTMS) 等,更容易复制. 这一发现推进了针对神经精神疾病的个性化神经调节.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
神经调节是一种神经调节.

背景情况:

非侵入性大脑刺激 (NIBS),包括重复性经磁性刺激 (rTMS),显示神经精神疾病的治疗承诺.
目前的rTMS准依赖于头皮启发式或结构性MRI,但个性化连接式方法正在出现.

研究的目的:

评估基于连接组的策略的可靠性和可重复性,用于RTMS刺激站点规划.
为了比较功能连接 (FC) 和结构连接 (SC) 的引导准方法.

主要方法:

在两个时间点获得多式磁共振成像 (MRI).
通过静止状态fMRI (FC) 和扩散张力成像 (SC) 来得出的刺激部位的个体内差异比较.

主要成果:

与功能连接 (FC) 导向的目标相比,结构连接 (SC) 导向的目标显示出更高的可重复性.
这表明基于SC的规划可能为rTMS提供更可靠的个性化.

结论:

基于Connectome的定位通过利用网络属性来增强rTMS的个性化.
SC引导的向似乎更可重现,因此需要在不同的患者群体中进一步验证,以推进个性化神经调节.

关键词:

扩散成像轨道图谱学扩散成像轨道图谱学侧面顶膜皮层的皮层.个性化大脑刺激个性化大脑刺激静止状态的功能连接.跨的磁性刺激

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