与心房相关的临床结果的参与者参与和偏好研究:PEARL-AF研究
Shelby D Reed1, Josephine L Harrington1, Daniel P Morin2
1Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA.
JACC. Advances
|November 21, 2024
概括
患者在考虑心房动治疗时,优先考虑避免死亡和严重中风而不是严重出血. 这些发现有助于从以患者为中心的角度评估抗凝剂对健康的净益处.
科学领域:
- 健康研究成果研究结果
- 患者偏好评估患者偏好评估
- 对心房动 (AF) 治疗评估的评估
背景情况:
- 量化患者对心房 (AF) 健康结果的偏好对于监管决策至关重要.
- 纳入患者的观点可以确保治疗与个人价值观保持一致.
研究的目的:
- 估计AF相关健康事件的相对重要性.
- 根据临床试验分析来计算抗凝剂对健康的净益处.
主要方法:
- 对1028名AF患者进行了偏好调查.
- 最好的最坏的缩放被用来评估各种AF相关事件的严重性,包括不同的中风严重程度,出血事件,心肌梗塞 (MI) 和死亡.
主要成果:
- 死亡被列为最严重的事件,其次是严重的致残性中风和严重出血或心力衰竭 (HF) 的MI.
- 轻微的中风,没有HF的MI和临床相关的非重大出血被列为最不严重的.
- 事件重要性排名在人口统计学方面是一致的,但相对权重因性别和种族而异.
结论:
- 患者对严重出血表示严重担忧,可与中度性中风或全身栓塞相比较.
- 估计的患者偏好权重可以促进以患者为中心的AF疗法的净益评估.
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