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奖励处理缺陷在家族前性痴呆症的早期出现

Noah G Cryns¹, Emily G Hardy¹, Ashlin R K Roy¹

¹Department of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, United States.

Frontiers in neuroscience

|November 21, 2024

概括

早期的奖励处理变化,包括对不愉快刺激的反应变化和努力减少,在行为变异前性痴呆症 (bvFTD) 患者中可以在症状出现之前就检测到. 这些发现有助于早期的bvFTD诊断.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
遗传学遗传学是一个

背景情况:

行为变异前性痴呆症 (bvFTD) 的特点是奖励处理中的显著变化,通常表现为对负面刺激的敏感性降低.
在疾病进展中早期检测这些奖励处理变化的方法仍然不清楚.

研究的目的:

调查bvFTD早期阶段的奖励处理变化的检测能力,包括无症状的基因突变载体.
检查奖励消费和与努力相关的行为是如何受到疾病严重程度和遗传状态的影响.

主要方法:

招募了具有已知progranulin (GRN),MAPT和C9orf72突变的家庭的参与者,将他们分为无症状非携带者,无症状携带者 (CDR 0),轻度症状携带者 (CDR 0.5) 和bvFTD患者.
管理的嗅觉任务涉及愉快,不愉快和中性刺激,以评估奖励评估和基于努力的决策.
分析了气味评级,接近/避免气味的选择,以及按按下率,以量化动机的努力和成功.

主要成果:

疾病严重程度较高的群体,包括轻微症状的携带者,对不愉快的气味评价更为积极 (p < 0.001).
与无症状组相比,轻度症状携带者和bvFTD患者更有可能选择闻到不愉快的气味.
轻度症状的携带者在嗅探任务中表现出明显较低的成功率和较少变化的努力 (分别为p = 0.048和p = 0.007).

结论:

奖励功能的变化,包括对负面刺激的不敏感性和动机减弱的努力,在bvFTD的早期可以检测到,甚至在符合正式诊断标准之前.
这些发现强调了识别明显的早期奖励变化的潜力,以促进更早,更准确的bvFTD诊断.
了解这些早期的症状变化可能会引导未来的研究对潜在的神经解剖学相关的指导.

关键词:

bvFTDD 这样就好了.痴呆症痴呆症是一种痴呆症.前性痴呆症前性痴呆症动机激励动机这是一个prodromal prodromal.奖励奖励奖励奖励奖励

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