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甲基扫描方法用于增强线性性天然产品efrapeptin C的生物活性

Yuanqi Lin1, Hiroaki Itoh1, Shingo Dan2

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan inoue@mol.f.u-tokyo.ac.jp.

Chemical science
|November 21, 2024
PubMed
概括

合成了Efrapeptin C类似物以改善抗癌活性. 在7位的甲基化显著提高了功效和稳定性,为药物开发提供了新的策略.

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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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