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Updated: Jun 7, 2025

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
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Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

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快速,强大和持久的共价化学探针来解构PI3Kα信号传输

Lukas Bissegger1, Theodora A Constantin1, Erhan Keles1

  • 1Department of Biomedicine, University of Basel Mattenstrasse 28 4058 Basel Switzerland matthias.wymann@unibas.ch +41 61 207 5046.

Chemical science
|November 21, 2024
PubMed
概括

研究人员为癌症研究开发了针对酸酸3-酶α (PI3Kα) 的新型共价化学探针. 这些探针具有卓越的功效和持续的PI3Kα信号抑制,有助于理解异型特异性功能和改善癌症治疗.

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