在2023年将诺基诺作为抗癌剂的药物重用
Asmaa E Kassab1, Rania M Gomaa2,3, Ehab M Gedawy1,3
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P. O. Box 11562 Cairo Egypt.
RSC advances
|November 21, 2024
概括
药物重新定位为癌症治疗提供了一种具有成本效益的方法. 诺基诺 (FQs) 通过抑制多酶II (Topo II) 来显示出作为新型抗癌剂的前景,从而有可能克服当前药物的局限性.
科学领域:
- 在瘤学瘤学.
- 药用化学 医学化学
- 药物发现 药物发现 药物发现
背景情况:
- 药物开发面临诸多挑战,包括高成本和监管障碍.
- 药物重新定位是一种有效的策略,可以为现有或失败的药物找到新的用途.
- 目前用于癌症的拓酶II (Topo II) 抑制剂具有抵抗性和毒性等局限性.
研究的目的:
- 审查最近 (2023) 关于诺基诺 (FQs) 抗癌潜力的研究.
- 探索FQs作为针对Topo II的重新定位的抗癌候选人.
- 总结FQ反扩散活动的结构-活动关系和机制.
主要方法:
- 对2023年发表的关于FQ和癌症的研究的文献综述.
- 对瘤细胞系和真核细胞Topo II的FQ疗效的分析.
- 评估FQ药物相似性和代谢性质.
主要成果:
- 实验性诺基诺 (FQs) 对瘤细胞表现出细胞毒性作用.
- FQs表现出对真核生物Topo II的强烈抑制.
- FQs具有有利的物理化学和代谢特性.
结论:
- 氨基 (FQs) 显示出作为抗癌剂重新定位的显著潜力.
- FQ 支架可以克服当前 Topo II 抑制剂的缺点.
- 进一步开发FQs可能会导致新的癌症治疗方法.
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