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Updated: Jun 7, 2025

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前皮紧接口的基因表达不受HIV暴露前预防的影响

Emily L Webb1, Stefan Petkov2, Heejin Yun3

  • 1Medical Research Council (MRC) International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Frontiers in immunology
|November 21, 2024
PubMed
概括

男性生殖道中的紧接点 (TJs) 对细胞完整性至关重要. 这项研究发现,暴露前预防 (PrEP) 没有改变TJ基因表达,支持其用于预防艾滋病毒的安全性.

关键词:
细胞因子 细胞因子埃姆特里西塔宾诺福维尔太阳皮是前皮的暴露前预防 PrEP 暴露前预防 PrEP紧密的结节 紧密的结节转录物 转录物 转录物

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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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