腹部缩综合征:特征和潜在的病理生理学
Igor A Suslin1, Iakov V Efimenko1, Ricardo Castrellon1
1Plastic Surgery, Larkin Community Hospital, Miami, USA.
Cureus
|November 21, 2024
概括
帕伦巴症,或类固醇肠,是运动员使用生长激素 (GH) 和胰岛素的罕见腹部缩症. 研究是有限的,表明使用类固醇可能会导致内脏脂肪和器官巨化,需要进一步研究.
科学领域:
- 内分泌学和运动医学 运动医学
- 生理学和病理生理学
背景情况:
- 腹部缩综合征,称为Palumboism或类固醇肠道,影响使用生长激素 (GH) 和胰岛素的运动员.
- 它的特点是显著的腹部膨胀和张张,其确切原因尚不清楚.
- 这种情况在职业健美界很普遍.
研究的目的:
- 进行关于Palumboism的综合文献审查.
- 探索这种疾病的潜在病理生理学和治疗方法.
- 发现当前研究中的差距,为未来的临床和外科管理奠定基础.
主要方法:
- 使用PubMed和其他来源进行了文献综述.
- 这些关键词包括"palumboism"",类固醇肠"",HGH肠"",胰岛素肠"",类固醇"和"生长激素".
- 纳入标准侧重于研究病理生理学,临床表现和管理的研究;最终审查中包括了30项研究.
主要成果:
- 没有发现专门针对Palumboism的同行评审研究,这表明存在重大研究缺陷.
- 事证据表明,长时间使用高剂量的类固醇,特别是人体GH和胰岛素,可能会导致Palumboism.
- 建议的机制包括内脏脂肪,器官巨和改变的原蛋白合成.
结论:
- 由于研究不足,对Palumboism缺乏全面的理解.
- 进一步的研究对于阐明其病理生理学,确定诊断标准和探索有效的治疗选择至关重要.
- 该审查强调了对这种影响运动员的疾病进行专门研究的必要性.
相关概念视频
01:22Appendicitis-I: Introduction
89
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
89
01:17Irritable Bowel Syndrome I: Introduction
247
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
247
01:24Obesity
379
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
379
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
01:24Chronic Pancreatitis I: Introduction
72
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
72
01:17Chronic Bowel Disorders: Introduction
388
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
388