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Updated: May 12, 2026

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation
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人类单细胞衍生的巨细胞根据它们的激活状态转移亚细胞金属蛋白酶活性

Eline Bernaerts1, Kourosh Ahmadzadeh1, Amber De Visscher1

  • 1Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.

iScience
|November 21, 2024
PubMed
概括

巨细胞根据其炎症或免疫抑制状态改变矩阵金属蛋白酶 (MMP) 的位置和活性. 这种蛋白酶调节会影响炎症中的巨细胞功能.

关键词:
生物科学 生物科学免疫反应的免疫反应.免疫学 免疫学 免疫学自然科学 自然科学

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...