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Updated: Jun 7, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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在多发性骨髓瘤中对免疫调节药物的耐药性:大脑细胞通路及其他方面

Phaik Ju Teoh1, Mun Yee Koh2, Constantine Mitsiades3

  • 1Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Division of Molecular and Cellular Oncology (MCO), Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, 02142. mdctpju@nus.edu.sg.

Haematologica
|November 21, 2024
PubMed
概括

在多发性骨髓瘤 (MM) 中对免疫调节药物 (IMiD) 获得的耐药性是一个挑战. 本综述探讨了未来IMiD疗法的新型CRBN独立的耐药性机制和策略.

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