使用不同聚合物的氨酸胺载口腔分解薄膜的配方和评估通过溶剂造方法
Özlem Çoban1, Kutsal Özcan1, Seçkin Engin2
1Karadeniz Technical University Faculty of Pharmacy, Department of Pharmaceutical Technology, Trabzon, Türkiye.
Turkish journal of pharmaceutical sciences
|November 21, 2024
概括
该研究开发了使用等和甘油的三氨乙化物 (TA) 的最佳口腔分解膜 (ODF),为患者提供更好的服药性和有效的口腔伤口局部治疗.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 口腔伤口需要有效的局部治疗.
- 目前用于Triamcinolone Acetonide (TA) 的局部配方包括奶油,凝和膏.
- 口腔分解膜 (ODF) 提供了一种新且可能更方便的输送方法.
研究的目的:
- 调查各种聚合物和塑化剂对TA装载ODF的性能的影响.
- 为了确定最适合患者应用和治疗疗效的配方.
- 评估不同ODF配方的物理特性和药物含量.
主要方法:
- 使用溶剂造方法制备了13种ODF配方.
- 评估的聚合物包括HPMC,聚乙烯醇,碳酸甲基纤维素,凝和pectin.
- 评估了物理特性 (外观,均性,pH值,机械耐用性,分解时间) 和药物含量.
主要成果:
- 凝,HPMC,聚乙醇,碳甲基纤维素和pectin产生了合适的ODF.
- 甘油增强了透明度和机械性能;PEG 400减少了重量变化.
- 一种以PEG 400 (ODF10) 为基础的质ODF表现出最佳的特性和药物含量合规性.
结论:
- 基于凝的ODF,特别是PEG 400的ODF10,非常适合用于TA的输送.
- 这些ODF提供了更好的易于应用,运输和精确的剂量,用于口腔伤口治疗.
- 开发含有TA的ODF代表了与现有的专题配方相比的重大进步.
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