在接受甲状腺手术的患者中,呼出的气息中的propofol度和BIS之间的相关性
Xiaoxiao Li1,2, Pan Chang1,2, Xing Liu1,2
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Journal of breath research
|November 21, 2024
概括
呼出的醇度 (Ce-pro) 与麻醉深度 (BIS) 的相关性很弱,但可以准确地预测延迟恢复. 将Ce-pro与其他因素结合起来,可以提高预测准确度,从而改善患者的治疗结果.
科学领域:
- 麻醉学 麻醉学
- 呼吸系统监测 呼吸系统监测
- 药理动力学 药理动力学
背景情况:
- 呼出醇度 (Ce-pro) 测量是一种潜在的非侵入性方法,用于监测麻醉的深度.
- 之前关于Ce-pro和双光谱指数 (BIS) 相对关系的研究受到小样本规模和方法问题的限制.
- 验证用于测量呼气中的仪器对于临床应用至关重要.
研究的目的:
- 为了研究手术内呼出醇度 (Ce-pro) 和双光谱指数 (BIS) 之间的相关性.
- 评估Ce-pro在预测全身麻醉后延迟恢复的准确性.
- 探索手术结束时Ce-pro的预测价值,单独和结合其他因素,延迟恢复.
主要方法:
- 包括100名在全身麻醉下接受选择性甲状腺手术的成年患者.
- 使用真空紫外线光电离子和飞行时间质谱测量来监测呼出的醇度 (Ce-pro).
- 双光谱指数 (BIS) 连续测量;线性混合效应模型分析了Ce-pro和BIS的关联.
主要成果:
- 在手术内Ce-pro和BIS之间发现了微弱的相关性 (边际R2 = 0.348).
- 在手术结束时,Ce-pro在预测延迟恢复方面表现出很好的准确性 (AUC = 0.75).
- 一个多因素模型,包括手术结束时的Ce-pro,性别,sufentanil剂量和麻醉持续时间,显示出更高的预测准确性 (AUC = 0.91).
结论:
- 在临床实践中,单独的手术内Ce-pro并不是麻醉深度的可靠指标.
- 手术结束时的Ce-pro显示出预测麻醉后延迟恢复的前景.
- 将手术结束时的Ce-pro与临床因素相结合,显著改善了延迟恢复的预测.
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